GEWICHT: 55 kg
Boobs: 75 DD Silikon
Services: Hetero, Klassische Massage, Fisting Klassiker, goldene Dusche, Handentspannung
This was randomized against a modified BFM protocol. From to , patients of age up to 18 years were registered in 10 centres and received after central randomization the allocated risk-stratified treatment. Until the s, the prognosis of children with acute lymphoblastic leukaemia ALL was extremely poor in Russia. First attempts to use modern intensive therapies gave poor results because of severe, mostly infectious complications and insufficient experience to manage them adequately due to lack of supportive care, mostly due to financial constraints.
Patients had to be hospitalized for long periods of time, and because of lacking accommodation facilities and long distances between their homes and the treatment institutions, the patients and their families were living in the hospital wards for months. Infections, in particular hepatitis B, transmitted by contaminated blood products, led to poor tolerance to treatment and thereby considerable delays. The protocol adherence varied largely, resulting in disparate survival rates. Hence, to offer these children a realistic chance for cure, there was an urgent need for a structured cooperative treatment approach, using a feasible protocol adapted to the specific requirements of the Russian conditions with consequent supportive care, accompanied by the advice and supervision of experienced paediatric haemato-oncologists, as well as offers to train Russian physicians and nurses abroad.
The results of this study are described below. From 1 August to 30 April , unselected consecutive patients up to 18 years of age with newly diagnosed precursor B- or T-cell ALL were assessed for eligibility in the 10 participating centres in Russia.
Written informed consent for enrolment to this study was obtained from the patient's guardians and the patient, if applicable, but was refused in 73 patients.